9 Plant Compounds That Activate Your Longevity Genes

5. Carvacrol — Supports mitophagy and cellular quality control

Carvacrol is another terpenoid abundant in oregano and thyme with promising links to mitophagy, the selective recycling of damaged mitochondria. Keeping mitochondria healthy matters because they supply cellular energy and influence how cells age. Early studies suggest carvacrol helps cellular clean-up systems work more efficiently, particularly under metabolic stress. In practical terms, adding oregano or thyme to sauces, roasted vegetables, and marinades provides a flavorful source of carvacrol. High-strength oregano oil supplements are available but can be intense and are best used under guidance. A food-first approach—seasoning dishes liberally with herbs—lets you benefit from these compounds while keeping things simple and safe.

6. Quercetin — A flavonoid that helps clear senescent cells

Quercetin is a common dietary flavonoid present in onions, apples, capers, and many berries. It’s attracted attention for senolytic properties—helping the body clear damaged, senescent cells that accumulate with age and can fuel inflammation. Research shows quercetin can work alongside other lifestyle measures to promote cellular renewal and reduce inflammatory signaling. Whole-food sources like sliced onions in salads, apples as snacks, and berries in breakfasts deliver quercetin as part of a nutrient-rich package. Some protocols pair quercetin supplements with other agents, but that’s a more clinical approach and not necessary for everyone. If you’re exploring supplements for targeted effects, consult a clinician so choices match your health needs and medications.