Risk Factors And Complications Of Pyoderma Gangrenosum
Pyoderma gangrenosum is a rare medical condition that causes the development of painful sores, which most often appear on the legs. Though the exact cause is unknown, the disorder seems to be linked to the immune system. Some underlying conditions can increase a person's risk of developing pyoderma gangrenosum. The ulcers usually clear up when they're treated, but they can leave behind scars, and it's also common for the ulcers to recur. The condition can occur at any age, though it more commonly affects individuals between twenty and fifty years old. Patients with pyoderma gangrenosum should try to avoid causing injury to their skin, as skin trauma can provoke the development of new ulcers.
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Rheumatoid Arthritis

More than fifty percent of patients with pyoderma gangrenosum have a systemic disease like rheumatoid arthritis, a chronic disorder that causes joint inflammation. Other systems in the body can become damaged as well, including the blood vessels, heart, lungs, eyes, and skin. Rheumatoid arthritis is an autoimmune disorder that starts when the immune system attacks tissues in the body. While osteoarthritis is caused by worn-down damage to the joints, rheumatoid arthritis causes the lining of the joints to become inflamed, leading to swelling that can, over time, cause deformity of the joint and erosion of bone. Symptoms include swollen joints, tender joints, joint stiffness that's worse after inactivity or in the mornings, fatigue, and fever.
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Acute Myelogenous Leukemia

There are three main blood cells in the body: red , white, and platelets. Red blood cells are responsible for carrying oxygen to the tissues throughout the body. They also move carbon dioxide to the lungs so it can be expelled. Platelets are fragments of cells that help blood clot. White blood cells are responsible for fighting infections in the body. Leukemias begin in cells that usually develop into blood cells, and the most common form of leukemia begins in the early white blood cells. While acute myelogenous leukemia starts in the bone marrow, it will often move into the blood itself. The disease can also spread to other systems in the body. When pyoderma gangrenosum and acute myelogenous leukemia are connected, it unfortunately often indicates a poor patient prognosis.
Keep reading to reveal more complications and risk factors of pyoderma gangrenosum.