Risk Factors And Complications Of Pyoderma Gangrenosum

Inflammatory Bowel Conditions

Patients with inflammatory bowel conditions, including Crohn's disease and ulcerative colitis, may be at a higher risk of developing pyoderma gangrenosum. Ulcerative colitis leads to chronic inflammation along with ulcers in the inner lining of the rectum and colon. Crohn's disease leads to inflammation in the digestive tract's lining, which can spread deeply into the tissues of the digestive tract. Both of these conditions tend to involve pain in the abdomen, weight loss, fatigue, and severe diarrhea. Doctors don't currently know what causes inflammatory bowel conditions. One theory is it's caused by a malfunction of the immune system. This may be why inflammatory bowel conditions and pyoderma gangrenosum have such a high rate of comorbidity, since the latter is also theorized to be caused by a malfunction of the immune system.

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Loss Of Mobility

The loss of mobility is a possible complication associated with pyoderma gangrenosum. When there are painful ulcers on the legs, it naturally becomes harder for a patient to move. One study involved a ninety-four-year-old man whose mobility was affected by the painful ulcers on his legs. It's important for patients to talk to a doctor if their ulcers are causing too much pain for normal mobility. The condition will often be treated with corticosteroids. These drugs mimic the hormone cortisol, which is created by the adrenal gland. They suppress the immune system. Since pyoderam gangrenosum is theorized to be caused by an overreaction of the immune system, corticosteroids help reduce the prevalence of ulcers. In addition, patients experiencing significant pain can sometimes benefit from prescribed pain medications.

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