12 Science-Backed Ways to Make the Ultimate Immune-Boosting Holiday Cocktail (Yes, Really!)

3. Citrus: Vitamin C and bright, immune-forward mixers

Fresh citrus juice is an easy way to add vitamin C and lively acidity to holiday cocktails. Oranges, grapefruits, and lemons bring both vitamin content and a sensory lift that pairs well with darker spirits and bubbly alike. For a simple citrus punch, combine freshly squeezed orange and grapefruit juice with a lower-proof spirit, sparkling water, and a touch of maple or honey to round the edges. Fresh juice loses vitamin C over time, so press citrus shortly before serving and keep chilled. If you’re watching sugar, balance a smaller citrus yield with herbs like rosemary or thyme for aromatic complexity. While a glass of citrus-y cocktail won’t replace a balanced diet, it adds nutrients and bright flavor to seasonal drinks without much effort.

4. Elderberry: Antioxidant punch for berry-forward cocktails

Elderberry syrup has become a popular winter ingredient because elderberries contain antioxidants called anthocyanins. Most human studies focus on non-alcoholic elderberry products for colds and flu, so treat alcoholic elderberry cocktails as a tasty way to enjoy the berry’s flavor and color rather than as proven prevention. A simple elderberry cordial—simmer dried elderberries, water, and a touch of sweetener, then strain—makes a versatile base. Mix cordial with sparkling wine or gin, top with club soda, and garnish with orange peel for a festive spritz. Store homemade cordials in the fridge and use within a couple of weeks. Elderberry adds seasonal depth and a jewel-toned look to drinks, but if you’re aiming purely for evidence-backed immune support, pair it with hydration and moderation rather than relying on alcohol as the delivery method.