11 Unexpected Benefits (and Risks) of Long-Term Antidepressant Use

11. The Surprising Link to Bone Health

Beyond the brain, neurotransmitters like serotonin play complex roles throughout the body – including potentially influencing bone strength. Some long-term studies, particularly involving SSRIs, have suggested a possible association between extended antidepressant use and decreased bone mineral density. This could subtly increase the risk of fractures over time, especially in older adults or those with other osteoporosis risk factors. While the connection isn't fully understood and the benefits of treating depression often far outweigh this potential risk, it highlights an unexpected physiological interplay worth discussing with your doctor, particularly regarding long-term use and bone health monitoring.