12 Common Over-the-Counter Meds with Surprising Side Effects

11. Redness-Relieving Eye Drops: The Rebound Trap

Got red eyes? Those ubiquitous drops promising "to get the red out" work by constricting blood vessels in the eye (vasoconstriction). While effective short-term, frequent, prolonged use can lead to a frustrating rebound effect: when the drop wears off, the vessels can dilate even more, making eyes appear redder than before, tempting further use. Additionally, though rare, systemic absorption of the vasoconstrictor, especially with overuse or in children, could potentially affect heart rate or blood pressure. Helpful Tip: Use these drops sparingly for occasional relief, not daily cosmetic whitening.

12. Heartburn Heroes (Beyond Antacids): PPIs & H2 Blockers

While simple antacids (#8) neutralize acid, other common OTC heartburn remedies work differently and have distinct considerations. Proton Pump Inhibitors (PPIs like omeprazole) drastically reduce acid production but long-term, consistent use (months/years) is linked to concerns like reduced nutrient absorption (B12, calcium, magnesium), potential kidney issues, and increased risk of certain infections like C. difficile. H2 Blockers (like famotidine) also reduce acid (less potently than PPIs) and are generally considered safer for longer use, but can still have side effects or interact with other drugs. Helpful Tip: Use the lowest effective dose for the shortest needed time.