12 Medications You Should Never Mix Without Asking Your Doctor

2. Antidepressants and Migraine Medications

Many migraine treatments, including triptans like sumatriptan (Imitrex) and rizatriptan (Maxalt), can interact dangerously with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), such as fluoxetine (Prozac), sertraline (Zoloft), and venlafaxine (Effexor). Mixing these medications can increase serotonin levels too much, leading to serotonin syndrome, a potentially life-threatening condition that causes confusion, high blood pressure, fever, and seizures. Always consult your doctor before combining antidepressants with migraine medications.