12 Medications You Should Never Mix Without Asking Your Doctor

Lisette Marie

3. Statins and Certain Antibiotics

Woman taking medication. Photo Credit: Envato @Hoverstock

Statins like atorvastatin (Lipitor) and simvastatin (Zocor) help lower cholesterol but can interact with certain antibiotics, including clarithromycin and erythromycin. These antibiotics can slow the breakdown of statins in the body, increasing the risk of muscle damage (rhabdomyolysis) and kidney failure. If you need antibiotics while on statins, your doctor may temporarily switch you to a different antibiotic or adjust your medication.

4. Blood Pressure Medications and Decongestants

Blood Pressure Check Up. Photo Credit: Envato @AnnaStills

Many people reach for decongestants like pseudoephedrine (Sudafed) when they have a cold or allergies. However, decongestants can raise blood pressure and counteract medications used to treat hypertension, such as beta-blockers, ACE inhibitors, and calcium channel blockers. If you have high blood pressure, check with your doctor before taking decongestants—safer alternatives, like saline nasal sprays or antihistamines, may be recommended.

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3. Statins and Certain Antibiotics

4. Blood Pressure Medications and Decongestants

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