12 Medications You Should Never Mix Without Asking Your Doctor

Lisette Marie

9. Acid Reducers and Certain Osteoporosis Medications

Acid reflux. Photo Credit: Envato @Chayantorn

Proton pump inhibitors (PPIs) like omeprazole (Prilosec) and esomeprazole (Nexium) reduce stomach acid and treat acid reflux. However, they can interfere with calcium absorption, weakening bones over time and increasing the risk of fractures—especially in people taking osteoporosis medications like bisphosphonates (alendronate, risedronate). If you're taking both medications, your doctor may recommend calcium and vitamin D supplements or alternative reflux treatments.

10. Thyroid Medications and Calcium or Iron Supplements

Supplements. Photo Credit: Envato @hannievanbaarle

Levothyroxine (Synthroid, Levoxyl) is a common treatment for hypothyroidism. However, calcium and iron supplements can interfere with its absorption, making it less effective. If you take both, separate them by at least four hours to ensure your body properly absorbs the thyroid medication.

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9. Acid Reducers and Certain Osteoporosis Medications

10. Thyroid Medications and Calcium or Iron Supplements

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