15 Unexpected Twists Your Body Takes With Diuretics

Akanksha Sharma

12. Mood Changes Or Fatigue

Tired office worker with burnout syndrome sleeping at work because of extreme fatigue. Photo Credit: Envato @DC_Studio

The electrolyte shifts caused by diuretics—particularly low sodium or potassium—can contribute to mood swings, irritability, or fatigue. Patients may feel sluggish, mentally foggy, or unusually emotional. These symptoms often improve once electrolyte levels are corrected. Bloodwork can determine if low levels of sodium (hyponatremia) or potassium are the root cause. In some cases, adjusting fluid intake, changing diet, or supplementing with electrolytes can improve symptoms without stopping the medication.

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12. Mood Changes Or Fatigue

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