15 Unexpected Twists Your Body Takes With Diuretics

5. Muscle Cramps

Nighttime muscle cramps are particularly common with diuretics, and they typically occur in the legs. Individuals who experience muscle cramps while taking diuretics might have lower than normal potassium. Since low potassium can cause irregular heart rhythms and other serious heart issues, patients with muscle cramps should ask their doctor if their potassium needs to be checked. Muscle cramps could also be a sign the diuretics have caused significant reductions in calcium, sodium, and magnesium, and patients might need to have blood tests to check these levels as well. Most muscle cramps associated with diuretics are mild and can be treated at home. Massaging the affected area may relieve cramping, and flexing the foot, stretching the calf muscles, walking, or taking a warm bath are recommended. To reduce the risk of muscle cramps at night, doctors suggest patients perform gentle leg stretches before going to bed. Drinking fluids can relieve cramping, but this is not advisable for patients on fluid restriction measures.

6. Skin Sensitivity To Sunlight

Diuretics—especially thiazide types—can increase sensitivity to sunlight, a condition known as photosensitivity. Patients may experience skin rashes, burning, or peeling after minimal sun exposure. Some may even develop a sunburn-like reaction despite using sunscreen. To reduce risk, it’s recommended to wear long sleeves, hats, and broad-spectrum SPF 30+ sunscreen when outdoors. If severe reactions occur, patients should speak with their doctor, who may adjust the medication or dosage. Regular skin checks and sun-avoidance strategies are especially important during summer months or in high UV regions.