15 Unexpected Twists Your Body Takes With Diuretics

7. Gout Flares

Certain diuretics, particularly thiazides, can raise uric acid levels in the blood, potentially triggering gout—a painful form of arthritis. Gout often causes sudden, severe joint pain, most commonly in the big toe, ankle, or knee. Swelling, redness, and warmth at the joint are hallmark signs. Patients with a history of gout should inform their doctor before starting diuretics. If a flare occurs, medications like colchicine or NSAIDs may be prescribed. Dietary modifications to reduce purine intake (found in red meat, shellfish, and alcohol) may also help manage uric acid levels.

8. Low Blood Pressure (Hypotension)

By reducing blood volume, diuretics can cause blood pressure to drop too low, leading to hypotension. Symptoms include dizziness, blurred vision, fainting, fatigue, and confusion—especially when standing up too quickly. This is known as orthostatic hypotension. Patients experiencing these symptoms should rise slowly from sitting or lying positions and discuss dosage adjustments with their doctor. In some cases, electrolyte rebalancing or switching to a different class of medication may be required to avoid further episodes.