15 Unexpected Twists Your Body Takes With Diuretics

7. Gout Flares

Certain diuretics, particularly thiazides, can raise uric acid levels in the blood, potentially triggering gout—a painful form of arthritis. Gout often causes sudden, severe joint pain, most commonly in the big toe, ankle, or knee. Swelling, redness, and warmth at the joint are hallmark signs. Patients with a history of gout should inform their doctor before starting diuretics. If a flare occurs, medications like colchicine or NSAIDs may be prescribed. Dietary modifications to reduce purine intake (found in red meat, shellfish, and alcohol) may also help manage uric acid levels.