Unexpected Twists and Turns in the Gabapentin Journey

11. The Memory Fog—Can Gabapentin Affect Cognitive Function?

Many patients report experiencing "brain fog" or short-term memory issues while on gabapentin. This phenomenon can manifest as forgetfulness, trouble focusing, difficulty finding words, or feeling mentally slow. While researchers are still exploring why this happens, it’s believed that gabapentin’s effect on calcium channels in the nervous system may alter cognitive function, particularly at higher doses. If memory issues persist, patients should discuss dose adjustments or alternative medications with their doctor. In some cases, lifestyle changes like staying hydrated, engaging in brain-stimulating activities, and getting quality sleep can help counteract this side effect.

12. The Kidney Connection—Why Dose Adjustments Matter

Gabapentin is primarily processed and excreted through the kidneys, which means that patients with kidney disease or impaired kidney function must take extra precautions. When the kidneys aren’t functioning properly, gabapentin can accumulate in the body, leading to symptoms such as severe drowsiness, dizziness, confusion, and even toxicity. Doctors typically adjust the dose based on a patient’s kidney function, measured by their creatinine clearance (CrCl) levels. Patients with chronic kidney disease (CKD) or those on dialysis may need significantly lower doses or extended dosing intervals to prevent harmful buildup.