Unexpected Facts About Omeprazole That Will Blow Your Mind

15. It May Influence Mental Health

There’s growing evidence that omeprazole and other PPIs might be linked to mental health changes, including increased risk of depression, anxiety, and cognitive issues. While the connection isn’t fully understood, researchers believe there are a few possible explanations. First, omeprazole's effect on nutrient absorption may play a role. Vitamin B12 deficiency, which can occur with prolonged PPI use, has been directly linked to mood disorders, memory loss, and cognitive decline. Additionally, magnesium deficiency—another side effect of PPIs—has been associated with increased stress and anxiety symptoms. Another theory suggests that omeprazole could affect neurotransmitter activity by altering the gut microbiome. Since the gut and brain are closely connected, changes in digestive bacteria could influence serotonin levels, which are crucial for mood regulation. While more research is needed, individuals who experience unexplained mood changes while on omeprazole may want to consult their doctor about alternative treatments.

16. It’s One of the Most Overused Medications

Omeprazole is often prescribed for longer than necessary, despite recommendations that it should be used short-term for most conditions. Many people end up taking it for years without realizing the risks associated with prolonged use. Studies have found that 30–50% of people taking PPIs long-term may not actually need them. Many patients continue using them without doctor supervision, sometimes as a habit or because they fear their symptoms will return. This overuse increases the risk of nutrient deficiencies, kidney disease, and rebound acid production. Doctors recommend regular check-ins for patients on omeprazole, and in many cases, lifestyle changes, dietary adjustments, or alternative medications may be safer options.