Unexpected Twists Your Body Takes on the Prednisone Adventure

12. Prednisone’s Strange Relationship with Sleep (Or Lack of It)

Prednisone has a stimulant-like effect, which means falling asleep—and staying asleep—can feel nearly impossible. Many users experience racing thoughts, vivid dreams, or night sweats, making a good night’s rest frustratingly elusive. Doctors often recommend taking it in the morning to mimic the body's natural cortisol cycle, reducing the risk of insomnia. But for those taking higher doses or long-term therapy, prednisone can disrupt sleep patterns for weeks or months after stopping.

13. The Surprising Weight Gain Mystery—And It’s Not Just About Eating More

Prednisone dramatically shifts metabolism, often causing rapid weight gain. While increased appetite plays a role, the drug also slows how the body processes carbohydrates, increases water retention, and encourages fat storage in unusual places (especially the face, neck, and abdomen). Many patients notice unexplained bloating or puffy facial features, even if their diet hasn’t changed. This effect is temporary for short-term users, but those on long-term prednisone may struggle with stubborn weight gain even after stopping the medication.