Unexpected Twists Your Body Takes on the Prednisone Adventure

14. Why Tapering Prednisone is Non-Negotiable

Stopping prednisone cold turkey is a recipe for disaster. Since the drug mimics cortisol, the body stops producing its own natural supply. If prednisone is suddenly withdrawn, the adrenal glands don’t have time to recover, leading to fatigue, dizziness, nausea, low blood pressure, and even adrenal crisis—a potentially life-threatening emergency. A slow, controlled taper allows the body to gradually restart cortisol production, preventing severe withdrawal symptoms.

15. Can Prednisone Weaken Your Bones? The Hidden Risk of Osteoporosis

Long-term prednisone use is a major cause of steroid-induced osteoporosis. The drug depletes calcium, reduces bone formation, and weakens bone density, increasing the risk of fractures—even from minor falls. Patients on long-term prednisone often need bone-strengthening medications, vitamin D, and lifestyle changes to counteract the effects. Even short-term users should ensure they’re getting enough calcium and exercise to minimize bone loss.