Overview Of Fluoxetine
Potential Medication Interactions

Fluoxetine should not be taken with pimozide, thioridazine, linezolid, or methylene blue injections. Patients who have used phenelzine, selegiline, rasagiline, or other monoamine oxidase inhibitors will need to wait to start fluoxetine until at least two weeks after discontinuing these medications. Individuals who take fluoxetine must wait at least five weeks after the drug is discontinued before they can safely take a monoamine oxidase inhibitor. Using fluoxetine with nonsteroidal anti-inflammatories could cause an increased risk of bleeding, and patients who take fluoxetine should check with their doctor before using acetylsalicylic acid, ibuprofen, naproxen, or any other anti-inflammatory medicine. Patients who take lithium and fluoxetine will need regular blood tests to check their lithium levels. Additionally, taking fluoxetine with risperidone, methadone, or aripiprazole could increase the patient's risk of experiencing heart rhythm changes, involuntary muscle movements, and serotonin syndrome. To reduce the risk of potential medication interactions, patients should let their doctor know about all of their current medications before adding fluoxetine.