Guide To Allopurinol
Potential Medication Interactions

Allopurinol has more than fifty potential medication interactions, including sixteen major ones. Patients should tell their doctor know about all of the medicines they take to help reduce the risk of these interactions. This includes prescriptions, over-the-counter drugs, herbal remedies, and vitamin supplements. Allopurinol can interact with certain antibiotics, including amoxicillin and ampicillin. In addition, the medication interacts with warfarin and other blood thinners. It also interacts with some chemotherapy drugs, including cyclophosphamide and mercaptopurine.
Medication interactions could occur if this medication is taken with diuretics or certain immunosuppressants as well. Patients who use these medications should check with their doctor before starting allopurinol. They may need to have their doses adjusted. Some individuals could be prescribed a different medicine. Patients who take probenecid, sulfinpyrazone, or other gout medicines should inform their doctor that they use these medicines too.