Guide To The Most Common Antidepressants

Serotonin Antagonist Reuptake Inhibitors

Serotonin antagonist reuptake inhibitors (SARIs), as the name indicates, prevent the reuptake of serotonin. However, it is also vital to note that they prevent certain serotonin particles, those released in a synapse, from binding to undesired receptors. Instead, they redirect them to the receptors that will help the nerve cells that affect an individual's mood work better. Two examples of medicines in this class are trazodone and nefazodone. Medications in this class treat major depression, but also act as an off-label treatment for anxiety and insomnia.

They have fewer side effects than older antidepressants. However, common side effects include fatigue, dry mouth, constipation, headache, and blurred vision. SARIs may interact with several other medications, including anti-inflammatories, blood thinners, and other antidepressants, like MAOIs and SSRIs.