Guide To Isoniazid
Potential Medication Interactions

Patients must review their current medications and supplements with their doctor before adding isoniazid. This includes any prescription and over-the-counter medicines. Doing so is vital to reduce the risk of potential medication interactions. Isoniazid interacts with quite a few medications. Examples include acetaminophen, some azole antifungals, and phenytoin.
It also causes interactions with some depression medications, including MAOIs and SSRIs. Examples of these include fluoxetine, sertraline, and isocarboxazid. Patients on these antidepressants often need to switch to another if they have to take isoniazid. Otherwise, doctors need to prescribe a different antibiotic.