What Are The Side Effects Of Antihistamines?

Confusion

Certain types of antihistamines are associated with confusion. This side effect is particularly pronounced in individuals over sixty-five years old. In fact, studies show an antihistamine called diphenhydramine may be associated with memory loss and an increased risk of dementia in this patient group. Seniors show reduced alertness, impairments in episodic memory, and diminished performance on memory tasks while taking diphenhydramine. The risk of confusion and memory issues seems to increase even more when antihistamines are used long-term. For example, a study conducted in senior patients at the University of Washington found that using antihistamines for three years increased the risk of developing dementia by fifty-four percent compared to using antihistamines for three months. Women who are sixty years old or older who take diphenhydramine with lorazepam have an elevated risk of confusion as well. Some health organizations suggest seniors avoid antihistamine use due to the strong likelihood of confusion and memory problems, and many doctors choose to prescribe an alternate drug for these patients. Individuals of all ages who experience confusion while taking an antihistamine should let their doctor know right away as it may be necessary to stop taking the medication.

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Moodiness

Moodiness is a recognized potential side effect of antihistamines. While it is most common in children, adults have also reported this symptom. Loratadine is one of the antihistamines most frequently associated with moodiness as a potential side effect, and moodiness has also been noted while on diphenhydramine. Patients have reported experiencing sudden depression while on this medication, and there have also been reports of paranoia, irritability, aggression, and angry outbursts. For loratadine users, the likelihood of experiencing depression may be increased with the use of the twelve-hour tablets designed for extended-release. Some individuals have reported suicidal thoughts while taking antihistamines. Since these mental health changes could be potentially serious, it is important to mention any mood changes to the prescribing physician urgently, especially in the case of sudden depression and suicidal thoughts. The patient should mention the mental changes began with the antihistamine use. It may be necessary to reduce the antihistamine dose, switch to another antihistamine, or switch to a different category of medicine. Patients who take over-the-counter antihistamines should be aware of the risk for mental health changes, and they should also speak to a doctor if these side effects occur while on the medication.

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