The Medication Trap: 11 Ways Your Sleep Aid May Be Contributing to Weight Gain
3. Antihistamines Used as Sleep Medications
Antihistamines like diphenhydramine (better known as Benadryl) and doxylamine show up in many over-the-counter “PM” sleep aids. By blocking histamine—a chemical involved in alertness—these medications can bring on drowsiness. However, that same blocking effect can slow metabolism and nudge appetite upward over time. Some studies suggest that frequent use of sedating antihistamines may be linked with slightly higher body mass index (BMI) values. While not everyone will notice a change, those who take these medications regularly should be mindful. If using antihistamines for sleep has become routine, check in with yourself about how you’re feeling—more sluggish, hungrier, or noticing changes in your weight. Reducing reliance on these medicines or trying natural sleep-promoting habits might gently support your overall wellness without unwanted side effects. As always, bring any new or persistent concerns to your healthcare team for individualized advice that honors your needs.
4. Antidepressants Prescribed for Insomnia
Several antidepressants are commonly prescribed “off-label” for sleep, especially when anxiety or depression is part of the picture. Trazodone and mirtazapine top this list. While these medications can soothe restless nights, mirtazapine in particular is known for its potential to boost appetite and contribute to weight gain in a number of people. This is partly due to the drug’s influence on neurotransmitters linked to hunger and satisfaction. Trazodone, by contrast, is generally considered more weight-neutral, but every body is unique. If your medication changes coincide with shifts in your appetite, cravings, or body weight, it’s not only reasonable but caring to bring this up with your clinician. Sleep and emotional wellness are both essential—your healthcare provider can help you balance these needs while minimizing unwanted effects. Compassion, patience, and dialogue are vital at each step.
