The Medication Trap: 11 Ways Your Sleep Aid May Be Contributing to Weight Gain

5. Over-the-Counter Melatonin

Melatonin is a naturally occurring hormone that signals to your body when it’s time for rest. Over-the-counter melatonin supplements promise a gentle, “natural” path to sleep, and for many, they can offer true relief. When it comes to weight gain, melatonin is usually considered safe and doesn’t directly appear to increase body weight in research studies. However, supplement products vary widely in quality and strength. Indirect impacts—like changing meal patterns due to altered sleep timing, or taking high doses—may eventually influence how your body stores or burns energy. Maintaining a consistent sleep and meal routine supports natural hormone rhythms and may help keep your metabolism in harmony. When using melatonin, purchase from reputable brands, take only what you need, and let your body guide you. For any supplement, it’s worthwhile to check in with your doctor to ensure it suits your whole health picture.

6. Combination Sleep Meds and Off-Label Prescribing

Sometimes, sleep medications may come packaged in combinations—either within one pill, or as several drugs prescribed together. In addition, many medications approved for other conditions, like antipsychotics or some anti-seizure drugs, are used “off-label” to promote sleep. These approaches can bring unpredictable side effects, especially related to metabolism and weight. Changes in appetite, energy, or body composition can feel confusing when the original prescription wasn’t just for sleep. If you’re taking multiple medications, or you’re unsure about all their intended effects, a routine medication review with your provider is an empowering step. Bring a list of everything you take, including over-the-counter drugs and supplements. Honoring your whole health means looking at the big picture—not just one symptom at a time.