Overview Of Vicodin
Potential Medication Interactions

Vicodin has potential medication interactions with more than 550 drugs. Taking Vicodin with certain medications used to treat Parkinson's disease, depression, migraines, or infections could lead to a potentially life-threatening side effect called serotonin syndrome. To reduce the risk of this serious interaction, patients should let their doctor know about all of the medicines they use before Vicodin is prescribed. In particular, it is important not to use Vicodin within fourteen days of taking MAO inhibitors. MAO inhibitors, which include isocarboxazid, linezolid, and phenelzine, are used to treat depression. Serious interactions also exist between Vicodin and other pain relievers that contain opioids, including butorphanol, which also interacts with naltrexone. Since Vicodin contains acetaminophen, patients will need to ask a doctor or pharmacist before taking any additional over-the-counter or prescription medicine that contains acetaminophen. Acetaminophen is commonly found in pain relievers, cold remedies, cough suppressants, allergy medicines, and sleep aids. If patients consume too much acetaminophen, liver damage could occur.